Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 6/20 | 0.45 |
| ▸ | MTTP | P55157 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802188 | 0.92 | MTTP (0.52) | APOBMTTPFLT1KDRSMO | |
| SCHEMBL6666569 | 0.88 | SMO (0.44) | APOBMTTPKDRSMOS1PR1 | |
| SCHEMBL6666524 | 0.88 | SMO (0.51) | APOBMTTPSMOS1PR1S1PR3 | |
| SCHEMBL6665703 | 0.85 | CYP11B1 (0.49) | APOBMTTPFLT1KDRSMO | |
| SCHEMBL6664413 | 0.84 | HTR2A (0.42) | APOBMTTPSMOHIF1AS1PR1 | |
| SCHEMBL6669784 | 0.84 | SMO (0.53) | APOBMTTPSMO | |
| SCHEMBL6642755 | 0.83 | SMO (0.49) | APOBMTTPSMOLMNA | |
| SCHEMBL6666013 | 0.82 | SMO (0.51) | APOBMTTPSMOS1PR1S1PR3 | |
| SCHEMBL6799860 | 0.81 | SMO (0.61) | APOBMTTPSMOKDM4EALDH1A1 | |
| SCHEMBL6665795 | 0.80 | APOB (0.44) | APOBMTTPKDRSMOALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383760-A1 | BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002090347-A1 | AMIDE COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-14 | — | — | WO | disclosed |