SCHEMBL6666042

SCHEMBL6666042

CC(=O)OC(C)c1cc2ccoc2cn1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1B P28222 2/20 0.38
CHRNA7 P36544 6/20 0.35
HTR3A P46098 3/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
HTR3E A5X5Y0 1/20 0.35
HTR3B O95264 1/20 0.35
HTR3D Q70Z44 1/20 0.35
HTR3C Q8WXA8 1/20 0.35
KMO O15229 1/20 0.34
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
PDE9A O76083 1/20 0.34
DYRK1A Q13627 1/20 0.33
CTNNB1 P35222 1/20 0.33
WNT3A P56704 1/20 0.33
FFAR1 O14842 1/20 0.32
BRD4 O60885 1/20 0.32
CREBBP Q92793 1/20 0.32
NAMPT P43490 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4671711 0.77 HTR1B (0.38) HTR1BCHRNA7HTR3AHTR3EHTR3B
SCHEMBL4670935 0.77 HTR1B (0.38) HTR1BCHRNA7HTR3AHTR3EHTR3B
SCHEMBL104574 0.77 HTR1B (0.38) HTR1BCHRNA7HTR3AHTR3EHTR3B
SCHEMBL11571906 0.77 CYP1A2 (0.41) S1PR1S1PR3PDE9AKDM4EPOLB
SCHEMBL3557371 0.75
SCHEMBL6670562 0.74 HTR1B (0.36) HTR1BCHRNA7HTR3AHTR3EHTR3B
SCHEMBL6667259 0.74 KDM4E (0.39) KDM4EPOLBMAPTHSD17B10
SCHEMBL55605 0.71 CHRNA7 (0.48) HTR1BCHRNA7HTR3AHTR3EHTR3B
SCHEMBL10754581 0.71 CCR1 (0.44) DYRK1AKDM4EPOLB
SCHEMBL843011 0.70 ALDH1A1 (0.42) CHRNA7HTR3ATAS1R3TAS1R1HTR3E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824524-B1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE UPJOHN CO (US) 2004-09-08 EP disclosed
EP-1449835-A2 Alpha-substituted pyrimidine-thioalkyl and alkylether compounds PHARMACIA & UPJOHN COMPANY (US) 2004-08-25 EP disclosed
US-6043248-A VIRICIDES FOR TREATING AN INDIVIDUAL INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS PHARMACIA & UPJOHN COMPANY (US) 2000-03-28 US disclosed
EP-0824524-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA & UPJOHN COMPANY (US) 1998-02-25 EP disclosed
WO-1996035678-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA & UPJOHN COMPANY (US) 1996-11-14 WO disclosed