Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5535472 | 0.81 | EPHX1 (0.47) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| SCHEMBL5046512 | 0.80 | RAPGEF4 (0.50) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| SCHEMBL6155871 | 0.78 | MAPT (0.53) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| Formamide SCHEMBL10553563 | 0.76 | MAPT (0.46) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| SCHEMBL9513146 | 0.74 | RAPGEF4 (0.68) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| SCHEMBL3624226 | 0.74 | RAPGEF4 (0.57) | MAPTRAPGEF4GAAALDH1A1MEN1 | |
| SCHEMBL16854124 | 0.73 | IDO1 (0.55) | GAAALDH1A1 | |
| SCHEMBL8419944 | 0.73 | GAA (0.61) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL20405623 | 0.73 | MAPT (0.44) | MAPTRAPGEF4GAAALDH1A1KMT2A | |
| SCHEMBL1143502 | 0.72 | RAPGEF4 (0.55) | MAPTRAPGEF4GAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |