Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | PRSS8 | Q16651 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6665971 | 0.93 | PSMB5 (0.52) | PSMB5CTSKCTSBRENELANE | |
| SCHEMBL6466347 | 0.86 | CTSK (0.58) | CTSKCTSLCTSSCAPN1CTSB | |
| SCHEMBL4460244 | 0.83 | ELANE (0.51) | PSMB5CTSKPRSS8CTSBREN | |
| SCHEMBL6665963 | 0.82 | PSMB5 (0.41) | PSMB5CTSKPRSS8CTSLCTSS | |
| SCHEMBL30480137 | 0.81 | CTSK (0.60) | PSMB5CTSKCTSLCTSSCAPN1 | |
| SCHEMBL9819550 | 0.79 | CTSK (0.63) | PSMB5CTSKCTSLCTSSCAPN1 | |
| SCHEMBL29308019 | 0.78 | PSMB5 (0.54) | PSMB5CTSKCTSLCTSSCAPN1 | |
| SCHEMBL30645063 | 0.77 | CTSK (0.60) | PSMB5CTSKCTSLCTSSCAPN1 | |
| SCHEMBL29813236 | 0.77 | CTSK (0.53) | PSMB5CTSKCTSLCTSSCTSB | |
| SCHEMBL19944603 | 0.77 | CTSK (0.58) | CTSKCTSLCTSSCAPN1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014882-A2 | PROTEASOME INHIBITORS : PEPTIDE DERIVATIVES HAVING C-TERMINAL HETEROARYL GROUPS | AXYS PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | claimed |
| WO-2004014882-A2 | PROTEASOME INHIBITORS : PEPTIDE DERIVATIVES HAVING C-TERMINAL HETEROARYL GROUPS | AXYS PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | disclosed |