Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.52 |
| ▸ | CTSK | P43235 | 9/20 | 0.48 |
| ▸ | CTSB | P07858 | 7/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667415 | 0.93 | PSMB5 (0.49) | PSMB5CTSKCTSBRENELANE | |
| SCHEMBL6665963 | 0.89 | PSMB5 (0.41) | PSMB5CTSKCTSBRENELANE | |
| SCHEMBL4460244 | 0.82 | ELANE (0.51) | PSMB5CTSKCTSBRENELANE | |
| SCHEMBL30500174 | 0.82 | PSMB5 (0.65) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL12826819 | 0.82 | PSMB5 (0.65) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL25465166 | 0.82 | PSMB5 (0.65) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL16024932 | 0.82 | PSMB5 (0.65) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL8343457 | 0.81 | CTSK (0.51) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL6683867 | 0.81 | CTSK (0.51) | PSMB5CTSKCTSBRENCASP1 | |
| SCHEMBL6662946 | 0.81 | PSMB5 (0.55) | PSMB5CTSKCTSBRENCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014882-A2 | PROTEASOME INHIBITORS : PEPTIDE DERIVATIVES HAVING C-TERMINAL HETEROARYL GROUPS | AXYS PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | claimed |
| WO-2004014882-A2 | PROTEASOME INHIBITORS : PEPTIDE DERIVATIVES HAVING C-TERMINAL HETEROARYL GROUPS | AXYS PHARMACEUTICALS (US) | 2004-02-19 | — | — | WO | disclosed |