Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558351 | 0.84 | GSK3A (0.65) | L3MBTL1MEN1KMT2AAPAF1GAA | |
| SCHEMBL4791747 | 0.84 | GSK3A (0.65) | L3MBTL1MEN1KMT2AAPAF1GAA | |
| SCHEMBL6908429 | 0.83 | CMA1 (0.49) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL14938439 | 0.81 | MEN1 (0.71) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL6407514 | 0.80 | MEN1 (0.64) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL30100689 | 0.80 | POLB (0.71) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL4328336 | 0.80 | POLB (0.71) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL30100692 | 0.80 | POLB (0.71) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL30492945 | 0.78 | GAA (0.49) | L3MBTL1MEN1KMT2ACASP3APAF1 | |
| SCHEMBL16163267 | 0.78 | L3MBTL1 (0.53) | L3MBTL1MEN1KMT2ACASP3APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345603-A4 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1345603-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002058695-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2002-08-01 | — | — | WO | disclosed |