Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673101 | 0.90 | HTR7 (0.65) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL6669515 | 0.83 | HTR7 (0.67) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL6668824 | 0.82 | HTR7 (0.62) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL29904797 | 0.80 | HTR7 (1.00) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL7755736 | 0.79 | ADRA2A (0.40) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| Irampanel SCHEMBL678128 | 0.78 | HTR7 (0.63) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL6670234 | 0.77 | HTR7 (0.67) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL6668813 | 0.77 | HTR7 (0.62) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| Irampanel SCHEMBL6879876 | 0.77 | HTR7 (0.62) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 | |
| SCHEMBL6562272 | 0.77 | HTR7 (0.62) | HTR7KDM4EALDH1A1SMN1; SMN2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077950-B1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6235738-B1 | BRAIN DISORDERS; ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-05-22 | — | — | US | disclosed |
| EP-1077950-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999054311-A1 | NOVEL DIPHENYL-SUBSTITUTED 6-RING-HETEROCYCLES, METHODS FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-28 | — | — | WO | disclosed |