Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671511 | 1.00 | PDE4D (0.46) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL9074021 | 1.00 | PDE4D (0.46) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL9074022 | 1.00 | PDE4D (0.46) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL6671515 | 1.00 | PDE4D (0.46) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL8432901 | 0.90 | PDE4D (0.44) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL578712 | 0.86 | PDE4D (0.47) | PDE4DBCHEACHESLC6A2TSHR | |
| SCHEMBL578711 | 0.86 | PDE4D (0.47) | PDE4DBCHEACHESLC6A2TSHR | |
| SCHEMBL578710 | 0.86 | PDE4D (0.47) | PDE4DBCHEACHESLC6A2TSHR | |
| SCHEMBL21948271 | 0.85 | PDE4D (0.43) | PDE4DBCHEPSEN1PSEN2APH1B | |
| SCHEMBL24477872 | 0.83 | CTSV (0.42) | PDE4DBCHEPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077383-B1 | SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS | EVOTEC INT GMBH (DE) | 2018-08-22 | — | — | EP | disclosed |
| EP-1237884-B1 | PROCESS FOR THE PREPARATION OF TRANS-3-ALKYLOXY-4-HYDROXYTETRAHYDROFURAN | EASTMAN CHEM CO (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1237884-A1 | PROCESS FOR THE PREPARATION OF TRANS-3-ALKYLOXY-4-HYDROXYTETRAHYDROFURAN | EASTMAN CHEMICAL COMPANY (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044222-A1 | PROCESS FOR THE PREPARATION OF TRANS-3-ALKYLOXY-4-HYDROXYTETRAHYDROFURAN | EASTMAN CHEMICAL COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |
| US-6140516-A | Process for the preparation of trans-3-alkyloxy-4-hydroxytetrahydrofuran | EASTMAN CHEMICAL COMPANY (US) | 2000-10-31 | — | — | US | disclosed |