Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079314 | 0.92 | ABCB1 (0.37) | ABCB1MAPTALDH1A1POLBPKM | |
| SCHEMBL6695580 | 0.90 | ALDH1A1 (0.43) | ABCB1MAPTALDH1A1POLBPKM | |
| SCHEMBL6690157 | 0.86 | KCNH2 (0.42) | MAPTPOLA1KCNH2 | |
| SCHEMBL6695578 | 0.86 | ABCB1 (0.40) | ABCB1MAPTALDH1A1POLBPKM | |
| SCHEMBL6691018 | 0.86 | KCNH2 (0.42) | MAPTPOLA1KCNH2 | |
| SCHEMBL6668075 | 0.85 | ABCB1 (0.38) | ABCB1MAPTALDH1A1POLBPKM | |
| SCHEMBL6672712 | 0.84 | POLA1 (0.41) | ABCB1MAPTSMN1; SMN2POLA1THRB | |
| SCHEMBL7086388 | 0.82 | ALDH1A1 (0.41) | ABCB1MAPTALDH1A1POLBPKM | |
| SCHEMBL6672226 | 0.82 | MAPK1 (0.36) | ALDH1A1 | |
| SCHEMBL6694399 | 0.81 | MAPT (0.41) | ABCB1MAPTALDH1A1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067947-A1 | Method of preventing or treating atherosclerosis or restenosis | WATHEN MICHAEL W | 2004-04-08 | — | — | US | claimed |
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | claimed |
| US-6624160-B2 | Especially infections of herpes simplex virus type 1, 2, 6, 7, or 8, varicella zoster virus, human cytomegalovirus or epstein-Barr virus; enzyme inhibitors of virus DNA polymerase | PHARMACIA & UPJOHN CO. | 2003-09-23 | — | — | US | claimed |
| EP-1265873-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | claimed |
| US-20020045619-A1 | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-04-18 | — | — | US | claimed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| US-20040067947-A1 | Method of preventing or treating atherosclerosis or restenosis | WATHEN MICHAEL W | 2004-04-08 | — | — | US | disclosed |
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6624160-B2 | Especially infections of herpes simplex virus type 1, 2, 6, 7, or 8, varicella zoster virus, human cytomegalovirus or epstein-Barr virus; enzyme inhibitors of virus DNA polymerase | PHARMACIA & UPJOHN CO. | 2003-09-23 | — | — | US | disclosed |
| EP-1265873-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| US-20020045619-A1 | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-04-18 | — | — | US | disclosed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045619-A1 | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, EIF2AK2 | ABCB1 810/4885MAPT 4784/4885ALDH1A1 575/4885 |
| US-20040067947-A1 | Method of preventing or treating atherosclerosis or restenosis | LDLR, MSR1, NR1H2 | ABCB1 2132/4885MAPT 4862/4885ALDH1A1 638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.