Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695580 | 0.92 | ALDH1A1 (0.43) | ALDH1A1LMNAPOLBPKMABCB1 | |
| SCHEMBL7079314 | 0.91 | ABCB1 (0.37) | ALDH1A1POLBPKMABCB1MAPT | |
| SCHEMBL7088275 | 0.88 | POLA1 (0.36) | LMNAABCB1MAPTTHRBTDP1 | |
| SCHEMBL7086001 | 0.84 | POLA1 (0.34) | LMNAABCB1MAPTTHRBTDP1 | |
| SCHEMBL7081528 | 0.84 | CACNA1C (0.35) | MAPTTHRBTDP1POLA1RXFP1 | |
| SCHEMBL7080399 | 0.83 | ABCB1 (0.37) | ALDH1A1POLBPKMABCB1MAPT | |
| SCHEMBL7086767 | 0.83 | POLA1 (0.38) | LMNAABCB1MAPTTHRBPOLA1 | |
| SCHEMBL6669520 | 0.82 | ABCB1 (0.39) | ALDH1A1POLBPKMABCB1MAPT | |
| SCHEMBL6690157 | 0.82 | KCNH2 (0.42) | MAPTPOLA1 | |
| SCHEMBL6691018 | 0.81 | KCNH2 (0.42) | MAPTPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | claimed |