Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25579654 | 0.79 | TAAR1 (0.44) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C | |
| SCHEMBL8067779 | 0.77 | TAAR1 (0.42) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C | |
| SCHEMBL1798685 | 0.77 | CYP1A2 (0.53) | TAAR1KMT2ASMN1; SMN2HTR2C | |
| Hydrochloric Acid SCHEMBL6167962 | 0.75 | CYP1A2 (0.52) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C | |
| SCHEMBL6161969 | 0.74 | TAAR1 (0.58) | TAAR1FNTAFNTB | |
| SCHEMBL8118171 | 0.74 | OPRM1 (0.47) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C | |
| SCHEMBL8239748 | 0.74 | TAAR1 (0.50) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C | |
| SCHEMBL8446859 | 0.72 | KDM1A (0.44) | TAAR1HPGDKMT2ASMN1; SMN2CHRM2 | |
| SCHEMBL1524562 | 0.72 | MAPT (0.44) | TAAR1HPGDKMT2ASMN1; SMN2USP2 | |
| SCHEMBL16876680 | 0.69 | ALDH1A1 (0.44) | TAAR1HPGDKMT2ASMN1; SMN2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198462-B1 | PROCESS FOR PREPARING A 10,11-METHANODIBENZOSUBERANE DERIVATIVE | LILLY CO ELI (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6624304-B1 | Halogenation, hydrofluorination, cyclization, salt formation, cyclization; reaction with piperazine; separation | ELI LILLY AND COMPANY | 2003-09-23 | — | — | US | disclosed |
| US-6570016-B1 | Therapy for drug resistant cancer | ELI LILLY AND COMPANY | 2003-05-27 | — | — | US | disclosed |