Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.68 |
| ▸ | CASP7 | P55210 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | FNTA | P49354 | 2/20 | 0.55 |
| ▸ | FNTB | P49356 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824403 | 0.82 | KDM4E (0.59) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL29612371 | 0.81 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL379103 | 0.81 | KDM4E (1.00) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL2884268 | 0.80 | GAA (0.46) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL2884271 | 0.80 | GAA (0.46) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL8167639 | 0.80 | MAPT (0.53) | KDM4EMAPTGAAALDH1A1CASP1 | |
| Hydrochloric Acid SCHEMBL1372439 | 0.80 | KDM4E (0.97) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL5211637 | 0.79 | ALDH1A1 (0.68) | KDM4EMAPTGAAALDH1A1CASP1 | |
| SCHEMBL15175557 | 0.78 | KDM4E (0.54) | KDM4EMAPTGAAALDH1A1MEN1 | |
| SCHEMBL11216214 | 0.77 | KDM4E (0.54) | KDM4EMAPTGAAALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324985-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1324985-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002028831-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2002-04-11 | — | — | WO | disclosed |