SCHEMBL667109

SCHEMBL667109

FC(F)(F)c1nnc2ccc(Br)cn12

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SCN5A Q14524 12/20 0.58
SCN1A P35498 1/20 0.53
SCN2A Q99250 1/20 0.53
ALDH1A1 P00352 1/20 0.42
CYP1A2 P05177 3/20 0.40
AHR P35869 1/20 0.39
MET P08581 1/20 0.38
KDM4E B2RXH2 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
RECQL P46063 1/20 0.37
KMT2A Q03164 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL938437 0.87 SMN1; SMN2 (0.47) SCN5ASCN1ASCN2AALDH1A1AHR
SCHEMBL23116008 0.83 SCN5A (0.48) SCN5ASCN1ASCN2AMETKDM4E
SCHEMBL1159892 0.82 SCN5A (0.41) SCN5ASCN1ASCN2AAHRMET
SCHEMBL4212574 0.81 SCN5A (0.46) SCN5ASCN1ASCN2AMETMEN1
SCHEMBL938219 0.78 SCN5A (0.44) SCN5ASCN1ASCN2ACYP1A2MET
SCHEMBL23116011 0.78 SCN5A (0.41) SCN5ASCN1ASCN2AALDH1A1CYP1A2
SCHEMBL23116199 0.78 SCN5A (0.41) SCN5ASCN1ASCN2AMETKDM4E
SCHEMBL31275134 0.78 SCN5A (0.58) SCN5ASCN1ASCN2AALDH1A1CYP1A2
SCHEMBL13757316 0.78 SCN5A (0.59) SCN5ASCN1ASCN2AALDH1A1CYP1A2
SCHEMBL5252065 0.78 SCN5A (0.58) SCN5ASCN1ASCN2AALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250129066-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2025-04-24 US disclosed
US-20250099448-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2025-03-27 US disclosed
WO-2024229221-A1 ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE CAPULUS THERAPEUTICS, LLC (US) 2024-11-07 WO disclosed
US-12030881-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-07-09 US disclosed
US-12030881-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-07-09 US disclosed
US-12030881-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-07-09 US disclosed
US-20220204505-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2022-06-30 US disclosed
US-11279700-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2022-03-22 US disclosed
US-11279700-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2022-03-22 US disclosed
US-20200377499-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2020-12-03 US disclosed
US-20120046271-A1 2,5-Methano- and 2,5-Ethano-Tetrahydrobenzazepine Derivatives And Use Thereof To Block Reuptake Of Norepinephrine, Dopamine, and Serotonin BRISTOL-MYERS SQUIBB COMPANY (US) 2012-02-23 US disclosed
WO-2012024397-A2 2,5-METHANO-AND 2,5-ETHANO-TETRAHYDROBENZAZEPINE DERIVATIVES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN ALBANY MOLECULAR RESEARCH, INC. (US) 2012-02-23 WO disclosed
US-8003649-B2 Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155 ASTRAZENECA AB (SE) 2011-08-23 US disclosed
WO-2011014462-A1 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS GILEAD PALO ALTO, INC. (US) 2011-02-03 WO disclosed
US-20110021521-A1 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS GILEAD PALO ALTO, INC. (US) 2011-01-27 US disclosed
US-20110021521-A1 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS GILEAD PALO ALTO, INC. (US) 2011-01-27 US disclosed
US-20110021521-A1 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS GILEAD PALO ALTO, INC. (US) 2011-01-27 US disclosed
EP-2235010-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS AstraZeneca AB (SE) 2010-10-06 EP disclosed
US-20100016279-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 ASTRAZENECA AB (SE) 2010-01-21 US disclosed
WO-2009081197-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS ASTRAZENECA AB (SE) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030881-B2 Ion channel modulators SCN1A, SCN1B, SCN2A SCN5A 5/4885SCN1A 1/4885SCN2A 3/4885
US-20120046271-A1 2,5-Methano- and 2,5-Ethano-Tetrahydrobenzazepine Derivatives And Use Thereof To Block Reuptake Of Norepinephrine, Dopamine, and Serotonin HTR2B, HTR1B, HTR5A SCN5A 159/4885SCN1A 377/4885SCN2A 371/4885
US-11279700-B2 Ion channel modulators SCN1A, SCN1B, SCN2A SCN5A 5/4885SCN1A 1/4885SCN2A 3/4885
US-20220204505-A1 ION CHANNEL MODULATORS SCN1A, SCN1B, SCN2A SCN5A 5/4885SCN1A 1/4885SCN2A 3/4885
US-20250099448-A1 HETEROCYCLIC COMPOUNDS OPRM1, CYP1A1, CYP3A4 SCN5A 354/4885SCN1A 681/4885SCN2A 1485/4885
US-20110021521-A1 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS KCNJ2, KCNH2, KCNA3 SCN5A 52/4885SCN1A 55/4885SCN2A 72/4885
US-20250129066-A1 ION CHANNEL MODULATORS SCN1A, SCN1B, SCN2A SCN5A 5/4885SCN1A 1/4885SCN2A 3/4885
US-20200377499-A1 ION CHANNEL MODULATORS SCN1A, SCN1B, SCN2A SCN5A 5/4885SCN1A 1/4885SCN2A 3/4885
US-20100016279-A1 BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS-155 AR, NR5A1, CYP17A1 SCN5A 1404/4885SCN1A 1826/4885SCN2A 3236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.