Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.66 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688153 | 0.81 | PTPN1 (0.66) | PTPN1MEN1KMT2AALOX5MGLL | |
| SCHEMBL1731203 | 0.81 | PTPN1 (0.66) | PTPN1PTPN2MGLL | |
| SCHEMBL643464 | 0.81 | PTPN1 (0.66) | PTPN1PTPN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6683753 | 0.80 | PTPN1 (0.69) | PTPN1PTPN2MEN1KMT2AMGLL | |
| SCHEMBL6690418 | 0.80 | PTPN1 (0.73) | PTPN1PTPN2MGLLALDH1A1ATM | |
| SCHEMBL1732116 | 0.80 | PTPN1 (1.00) | PTPN1PTPN2MEN1KMT2AALOX5 | |
| SCHEMBL1731402 | 0.78 | PTPN1 (0.96) | PTPN1PTPN2MEN1KMT2AALOX5 | |
| SCHEMBL1732288 | 0.78 | PTPN1 (0.65) | PTPN1MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL15158748 | 0.78 | PTPN1 (0.60) | PTPN1PTPN2MEN1KMT2AALOX5 | |
| SCHEMBL3609861 | 0.78 | PTPN1 (0.60) | PTPN1PTPN2MEN1KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |