Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672718 | 0.87 | PTPN1 (0.59) | PTPN1HTTMGLLHTR1AHTR7 | |
| SCHEMBL6689304 | 0.86 | PTPN1 (0.81) | PTPN1ALDH1A1FAAHMGLLUSP2 | |
| SCHEMBL1732116 | 0.85 | PTPN1 (1.00) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL1731402 | 0.84 | PTPN1 (0.96) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL5129161 | 0.80 | PTPN1 (0.61) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL643464 | 0.80 | PTPN1 (0.66) | PTPN1ALDH1A1USP2PTPN2 | |
| SCHEMBL1731203 | 0.80 | PTPN1 (0.66) | PTPN1FAAHMGLLSLC40A1PTPN2 | |
| SCHEMBL1688153 | 0.80 | PTPN1 (0.66) | PTPN1HSP90AA1MGLLHSD17B10 | |
| SCHEMBL6684475 | 0.80 | PTPN1 (0.66) | PTPN1ALDH1A1ATMMGLLPTPN2 | |
| SCHEMBL1732288 | 0.79 | PTPN1 (0.65) | PTPN1ALDH1A1USP2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |