SCHEMBL6672820

SCHEMBL6672820

N#CC(C#N)=CC1C(=O)C(=O)c2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 0.38
EDNRB P24530 3/20 0.37
EDNRA P25101 3/20 0.37
TRPA1 O75762 1/20 0.34
CYP1A2 P05177 1/20 0.32
MAPK1 P28482 1/20 0.32
EPHX2 P34913 1/20 0.31
USP8 P40818 1/20 0.31
USP7 Q93009 1/20 0.31
TYR P14679 1/20 0.31
PPIA P62937 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
APAF1 O14727 1/20 0.31
TDP2 O95551 1/20 0.31
CDC25B P30305 1/20 0.30
PPME1 Q9Y570 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28822304 0.80 MCL1 (0.35) PIM1MAPK1MEN1KMT2AALDH1A1
SCHEMBL2955165 0.70 AR (0.36) PIM1EDNRBEDNRATRPA1MAPK1
SCHEMBL30991817 0.70 AR (0.36) PIM1EDNRBEDNRATRPA1MAPK1
SCHEMBL29144668 0.68 PIM1 (0.61) PIM1EDNRBEDNRACYP1A2MAPK1
SCHEMBL11663620 0.65 EDNRB (0.47) EDNRBEDNRACYP1A2MAPK1EPHX2
SCHEMBL8629993 0.65 TRPA1 (0.40) TRPA1MAPK1MEN1KMT2AALDH1A1
SCHEMBL7421342 0.62 GPR3 (0.41) PIM1CYP1A2MEN1KMT2AALDH1A1
SCHEMBL14178916 0.61 MAPK1 (0.44) PIM1EDNRBEDNRACYP1A2MAPK1
SCHEMBL29285411 0.61 MAPK1 (0.44) PIM1EDNRBEDNRACYP1A2MAPK1
SCHEMBL14178919 0.61 TYR (0.44) EDNRBEDNRACYP1A2MAPK1TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985968-B1 Liquid crystalline filter dyes for imaging elements EASTMAN KODAK CO (US) 2004-10-06 EP disclosed
US-6527977-B2 Solvent dispersion EASTMAN KODAK COMPANY 2003-03-04 US disclosed
US-6455210-B1 SUPPORT, PHOTOTHERMOGRAPHIC IMAGE- RECEIVING LAYERS, AND ANTIHALATION LAYER OR FILTER LAYERS OF A DYE AND A HEXAARYLBIIMIDAZOLE IN A DISPERSION OF A HYDROPHILIC POLYMER EASTMAN KODAK COMPANY 2002-09-24 US disclosed
US-20020106590-A1 AQUEOUS THERMALLY BEACHABLE COMPOSITION USEFUL IN A PHOTOTHERMOGRAPHIC ELEMENT CARESTREAM HEALTH, INC. 2002-08-08 US disclosed
EP-1217431-A2 An aqueous thermally bleachable composition useful in a photothermographic element EASTMAN KODAK COMPANY (US) 2002-06-26 EP disclosed
US-6355386-B1 FOR PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY 2002-03-12 US disclosed
US-20020009656-A1 Liquid crystalline filter dyes for imaging elements EASTMAN KODAK COMPANY 2002-01-24 US disclosed
US-6214499-B1 Liquid crystalline filter dyes for imaging elements EASTMAN KODAK COMPANY 2001-04-10 US disclosed
US-6180295-B1 CONTAINING MEROCYANINE DYE EASTMAN KODAK COMPANY 2001-01-30 US disclosed
EP-0985970-A1 Liquid crystalline filter dyes for imaging elements EASTMAN KODAK COMPANY (US) 2000-03-15 EP disclosed
EP-0985968-A1 Liquid crystalline filter dyes for imaging elements EASTMAN KODAK COMPANY (US) 2000-03-15 EP disclosed