Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667111 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL31122224 | 0.77 | POLB (0.38) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6966322 | 0.74 | POLB (0.36) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8489689 | 0.74 | POLB (0.36) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10714528 | 0.72 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6673370 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2POLBCYP3A4 | |
| SCHEMBL16619262 | 0.71 | HSP90AA1 (0.38) | KDM4EALDH1A1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL8936657 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6319129 | 0.70 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6278027 | 0.70 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-A4 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-02-11 | — | — | EP | disclosed |
| EP-1066286-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999045009-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-10 | — | — | WO | disclosed |