Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.39 |
| ▸ | PDE4A | P27815 | 14/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675416 | 0.94 | KDM4E (0.43) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL6677308 | 0.94 | PDE4A (0.42) | PDE4BPDE4DPDE4APDE4CRXFP1 | |
| SCHEMBL6679248 | 0.91 | MEN1 (0.43) | MEN1KMT2ARXFP1KDM4EUSP2 | |
| SCHEMBL6673141 | 0.87 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL6675937 | 0.84 | ALDH1A1 (0.51) | MEN1KMT2ARXFP1KDM4EUSP2 | |
| SCHEMBL6673145 | 0.82 | ALDH1A1 (0.47) | MEN1KMT2ARXFP1KDM4EUSP2 | |
| SCHEMBL7026709 | 0.82 | PDE4B (0.41) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8409717 | 0.77 | KDM4E (0.46) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6673366 | 0.77 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6673641 | 0.77 | PDE4A (0.48) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202628-B1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2004-10-13 | — | — | EP | disclosed |
| EP-1169321-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| EP-1202628-A4 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |
| EP-1202628-A1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | Euro-Celtique S.A. (LU) | 2002-05-08 | — | — | EP | disclosed |
| EP-1169321-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2002-01-09 | — | — | EP | disclosed |
| WO-2001011967-A1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2001-02-22 | — | — | WO | disclosed |
| WO-2000059449-A2 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2000-10-12 | — | — | WO | disclosed |