Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28503258 | 0.81 | RAB9A (0.47) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2643483 | 0.79 | NPC1 (0.67) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL29496951 | 0.79 | NPC1 (0.67) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL29496950 | 0.79 | NPC1 (0.67) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL26783309 | 0.77 | KEAP1 (0.57) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL6738366 | 0.76 | TSHR (0.76) | MAPTIDO1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30914344 | 0.76 | MAPT (0.63) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL929507 | 0.76 | MAPT (0.63) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL30461136 | 0.76 | RAB9A (0.69) | MAPTKEAP1NFE2L2IDO1RAB9A | |
| SCHEMBL30461135 | 0.76 | RAB9A (0.69) | MAPTKEAP1NFE2L2IDO1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904262-B1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6472414-B1 | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-29 | — | — | US | disclosed |
| EP-0904262-A4 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0904262-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| US-5760246-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 1998-06-02 | — | — | US | disclosed |
| WO-1997026240-A1 | CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |