Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700945 | 0.91 | CA2 (0.54) | ALDH1A1THRBGAACA12CA2 | |
| SCHEMBL7178620 | 0.84 | ADRB1 (0.67) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| SCHEMBL233850 | 0.84 | ADRB1 (0.67) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| Hydrochloric Acid SCHEMBL29882384 | 0.83 | MAPT (0.65) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| Hydrochloric Acid SCHEMBL2961970 | 0.83 | MAPT (0.65) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| SCHEMBL7474849 | 0.80 | ADRB1 (0.61) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| SCHEMBL5239716 | 0.79 | ADRB1 (0.59) | MAOBADRB1HTR6ALDH1A1HTR3E | |
| SCHEMBL6242244 | 0.79 | CA2 (0.54) | THRBGAACA12CA2CA9 | |
| SCHEMBL2156809 | 0.77 | KDM4E (0.55) | ALDH1A1MAPTTHRBKDM4EGAA | |
| SCHEMBL4698660 | 0.77 | CA2 (0.56) | THRBGAACA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444202-A1 | NOVEL METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040098-A1 | NOVEL METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |