SCHEMBL6675147

SCHEMBL6675147

CCN=C(N)Nc1ccc(OC)c(C(C)N)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 2/20 0.49
MAPT P10636 3/20 0.41
ALDH1A1 P00352 2/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
ALOX12 P18054 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
ADRA2A P08913 5/20 0.40
CYP2D6 P10635 1/20 0.40
ADRA1A P35348 1/20 0.40
KMT2A Q03164 5/20 0.39
MEN1 O00255 3/20 0.39
MAPK1 P28482 2/20 0.39
BLM P54132 1/20 0.39
POLB P06746 1/20 0.38
SIGMAR1 Q99720 1/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP1A2 P05177 2/20 0.36
CYP2C19 P33261 2/20 0.36
C5AR1 P21730 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6676217 0.99 PTGIR (0.48) PTGIRMAPTALDH1A1LMNATP53
SCHEMBL6680859 0.78 PTGIR (0.51) PTGIRMAPTALDH1A1LMNATP53
Hydrochloric Acid SCHEMBL6676156 0.77 PTGIR (0.50) PTGIRMAPTALDH1A1LMNATP53
SCHEMBL6678298 0.76 PTGIR (0.49) PTGIRMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL6678263 0.76 PTGIR (0.49) PTGIRMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL6675391 0.76 HTT (0.43) MAPTALDH1A1LMNATP53ALOX12
Hydrochloric Acid SCHEMBL6676216 0.75 HTT (0.42) MAPTALDH1A1LMNATP53ALOX12
Hydrochloric Acid SCHEMBL7245284 0.75 ALDH1A1 (0.49) PTGIRALDH1A1ADRA2AKMT2AMEN1
Hydrochloric Acid SCHEMBL6684024 0.75 PTGIR (0.48) PTGIRMAPTALDH1A1LMNAADRA2A
SCHEMBL6675654 0.74 PTGIR (0.49) PTGIRADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0798292-B1 ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) 2004-11-03 EP claimed
EP-1432749-A1 POLYURETHANE ELASTOMERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE Bayer MaterialScience AG (DE) 2004-06-30 EP disclosed
WO-2003020783-A1 POLYURETHANE ELASTOMERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE BAYER MATERIALSCIENCE AG (DE) 2003-03-13 WO disclosed