SCHEMBL6675552

SCHEMBL6675552

CC(=O)N1C[C@H]2CCCC[C@@H]2C1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.58
CHRNA3 P32297 3/20 0.58
CHRNA4 P43681 3/20 0.58
CHRNB4 P30926 2/20 0.58
HSD11B1 P28845 4/20 0.56
CHRNB3 Q05901 1/20 0.48
CHRNA6 Q15825 1/20 0.48
CHRNA7 P36544 1/20 0.43
EPHX2 P34913 3/20 0.42
EPHX1 P07099 1/20 0.42
HSD11B2 P80365 1/20 0.38
CCR5 P51681 1/20 0.38
CYP1A2 P05177 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
GAA P10253 1/20 0.35
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6674224 1.00 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL6674226 1.00 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL11204341 0.98 HSD11B1 (0.59) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL11204345 0.98 HSD11B1 (0.59) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL11201571 0.95 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL1569444 0.95 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL20343709 0.95 CHRNB2 (0.58) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL18711710 0.87 HSD11B1 (0.53) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL18478535 0.87 HSD11B1 (0.53) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1
SCHEMBL879232 0.87 HSD11B1 (0.53) CHRNB2CHRNA3CHRNA4CHRNB4HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0899259-B1 Process for the preparation of cis-hexahydroisoindolines YUKI GOSEI YAKUHIN KOGYO KK (JP) 2004-10-13 EP disclosed
US-5932744-A Process for the preparation of cis-hexahydroisoindoline derivatives YUKI GOSEI KOGYO CO., LTD. (JP) 1999-08-03 US disclosed
EP-0899259-A1 Process for the preparation of cis-hexahydroisoindolines YUKI GOSEI KOGYO CO., LTD. (JP) 1999-03-03 EP disclosed