Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878189 | 0.89 | HDAC3 (0.43) | CYP2C19HIF1AKEAP1NR4A2HDAC3 | |
| SCHEMBL4591664 | 0.81 | CYP2C19 (0.42) | CYP2C19HIF1AKEAP1HDAC3HDAC4 | |
| SCHEMBL8056864 | 0.79 | MAPT (0.33) | CYP2C19HIF1ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL506540 | 0.79 | NR1H2 (0.33) | CYP2C19HIF1AMAPTNPC1RAB9A | |
| SCHEMBL6312176 | 0.76 | TSHR (0.34) | CYP2C19SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL21834438 | 0.75 | SLC13A5 (0.43) | CYP2C19HIF1AMAPTALDH1A1CYP1A2 | |
| SCHEMBL13320021 | 0.74 | MAPT (0.39) | CYP2C19HIF1AHDAC3HDAC4HDAC1 | |
| SCHEMBL15564536 | 0.74 | NR1H2 (0.33) | HIF1AMAPTNPC1RAB9ATSHR | |
| SCHEMBL8701181 | 0.74 | CYP2C19 (0.38) | CYP2C19HIF1AMAPTNPSR1ALDH1A1 | |
| SCHEMBL7822716 | 0.74 | KEAP1 (0.46) | CYP2C19HIF1AKEAP1NR4A2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458746-A2 | CYCLIC TETRAPEPTIDE COMPOUND AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003057722-A2 | CYCLIC TETRAPEPTIDE COMPOUND AND USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-17 | — | — | WO | disclosed |