Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.73 |
| ▸ | RET | P07949 | 6/20 | 0.73 |
| ▸ | KIF5B | P33176 | 4/20 | 0.73 |
| ▸ | EGFR | P00533 | 10/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.72 |
| ▸ | JAK3 | P52333 | 2/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | STK10 | O94804 | 1/20 | 0.72 |
| ▸ | FLT3 | P36888 | 1/20 | 0.72 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.72 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.72 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.72 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.72 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.72 |
| ▸ | LCK | P06239 | 3/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 2/20 | 0.65 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20792806 | 0.91 | EGFR (0.87) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL3533221 | 0.91 | EGFR (0.80) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL14159636 | 0.90 | KDR (0.73) | KDRRETKIF5BEGFRRIPK2 | |
| Hydrochloric Acid SCHEMBL8871198 | 0.89 | EGFR (0.80) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL13604745 | 0.88 | EGFR (0.82) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL6674055 | 0.88 | KDR (0.82) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL4970955 | 0.86 | RET (0.68) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL6689820 | 0.85 | AURKB (0.73) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL907182 | 0.85 | KDR (0.77) | KDRRETKIF5BEGFRRIPK2 | |
| SCHEMBL14964757 | 0.85 | EGFR (0.81) | KDRRETKIF5BEGFRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004040003-A2 | NUCLEOTIDE-BINDING PROTEIN-DIRECTED PROBES AND METHODS OF THEIR SYNTHESIS AND USE | ACTIVX BIOSCIENCES, INC. (US) | 2004-05-13 | — | — | WO | disclosed |