Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.82 |
| ▸ | RET | P07949 | 6/20 | 0.82 |
| ▸ | RAF1 | P04049 | 4/20 | 0.74 |
| ▸ | BRAF | P15056 | 3/20 | 0.74 |
| ▸ | KIF5B | P33176 | 2/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.69 |
| ▸ | FLT1 | P17948 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.69 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.69 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 9/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.63 |
| ▸ | GAK | O14976 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569018 | 0.90 | KDR (1.00) | KDRRETRAF1KIF5BEPHB2 | |
| Hydrochloric Acid SCHEMBL1507643 | 0.89 | KDR (0.97) | KDRRETRAF1KIF5BEPHB2 | |
| SCHEMBL13604745 | 0.89 | EGFR (0.82) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL2100551 | 0.88 | EGFR (0.82) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL6675906 | 0.88 | KDR (0.73) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL22367405 | 0.87 | EGFR (0.82) | KDRRETKIF5BEPHB2FGFR1 | |
| SCHEMBL10101988 | 0.87 | EGFR (0.82) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL15052226 | 0.85 | BRAF (1.00) | RAF1BRAF | |
| SCHEMBL5239599 | 0.85 | EGFR (0.80) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL13285584 | 0.84 | EGFR (0.83) | KDRRETRAF1BRAFKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004040003-A2 | NUCLEOTIDE-BINDING PROTEIN-DIRECTED PROBES AND METHODS OF THEIR SYNTHESIS AND USE | ACTIVX BIOSCIENCES, INC. (US) | 2004-05-13 | — | — | WO | disclosed |