Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.48 |
| ▸ | CA2 | P00918 | 9/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | FPR3 | P25089 | 3/20 | 0.40 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677827 | 0.94 | NAMPT (0.53) | CA1CA2NAMPTCA12CA9 | |
| SCHEMBL6676314 | 0.87 | NAMPT (0.51) | CA1CA2NAMPTFPR3FPR2 | |
| SCHEMBL6680723 | 0.81 | CYP3A4 (0.45) | CA1CA2NAMPTSIGMAR1 | |
| SCHEMBL6680783 | 0.81 | CA1 (0.40) | CA1CA2NAMPTCA12CA9 | |
| SCHEMBL6678162 | 0.81 | PRMT1 (0.40) | CA1CA2NAMPTFPR3FPR2 | |
| SCHEMBL6681824 | 0.80 | NQO2 (0.39) | CA1CA2NAMPTCA12CA9 | |
| SCHEMBL4879584 | 0.78 | MGLL (0.52) | CA1CA2CA12CA9SIGMAR1 | |
| SCHEMBL6686317 | 0.77 | ITGB3 (0.49) | — | |
| SCHEMBL6676230 | 0.77 | PTPN11 (0.38) | CA1CA2NAMPTF2FPR3 | |
| SCHEMBL7237067 | 0.77 | ITGB3 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |