Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677458 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HTTSNCALMNATDP1 | |
| SCHEMBL6680663 | 0.80 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1HTTTUBB4ATUBB | |
| SCHEMBL6641000 | 0.75 | ALDH1A1 (0.46) | KMT2ASMN1; SMN2ALDH1A1HTTTUBB4A | |
| SCHEMBL5191594 | 0.74 | SNCA (0.49) | ALDH1A1SNCATDP1 | |
| SCHEMBL6674343 | 0.74 | ALDH1A1 (0.38) | KMT2ASMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL6278012 | 0.73 | KMT2A (0.46) | KMT2ASMN1; SMN2ALDH1A1HTTTUBB4A | |
| SCHEMBL1627019 | 0.73 | TSHR (0.44) | KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL283204 | 0.72 | SMN1; SMN2 (0.42) | KMT2ASMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL6643273 | 0.72 | ALDH1A1 (0.46) | KMT2ASMN1; SMN2ALDH1A1HTTTUBB4A | |
| SCHEMBL6581247 | 0.72 | ALDH1A1 (0.46) | KMT2ASMN1; SMN2ALDH1A1HTTTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |