Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 5/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676204 | 0.82 | MEN1 (0.46) | KMT2AMEN1NR1H3SCN2APIM3 | |
| SCHEMBL6678967 | 0.78 | NR1H3 (0.54) | KMT2AMEN1NR1H3GRM1 | |
| SCHEMBL21996408 | 0.76 | CASP3 (0.52) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL6676671 | 0.76 | KMT2A (0.72) | KMT2AMEN1NR1H3SCN2APIM3 | |
| SCHEMBL4594655 | 0.73 | NR1H3 (0.62) | KMT2AMEN1NR1H3SCN2AGAA | |
| SCHEMBL9454327 | 0.72 | NR1H3 (0.71) | KMT2AMEN1NR1H3SCN2AGAA | |
| SCHEMBL7360730 | 0.72 | SCN2A (0.62) | KMT2AMEN1NR1H3SCN2APIM3 | |
| SCHEMBL10999030 | 0.72 | KMT2A (0.62) | KMT2AMEN1NR1H3SCN2APIM3 | |
| Bromide SCHEMBL4875685 | 0.71 | NR1H3 (0.60) | KMT2AMEN1NR1H3SCN2AGAA | |
| SCHEMBL4649471 | 0.71 | KMT2A (0.78) | KMT2AMEN1NR1H3SCN2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| CN-1075808-C | Aniline derivatives having nitric oxide synthase inhibitory activity | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2001-12-05 | — | — | CN | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |