SCHEMBL6676330

SCHEMBL6676330

CCc1c(C)oc2cccc(C(=O)O)c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APEX1 P27695 1/20 0.43
ALDH1A1 P00352 5/20 0.40
HSD17B10 Q99714 2/20 0.40
HPGD P15428 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CA12 O43570 2/20 0.39
CA9 Q16790 2/20 0.39
CA2 P00918 1/20 0.39
CLCN2 P51788 1/20 0.39
EDNRA P25101 2/20 0.38
MYC P01106 1/20 0.37
ALOX15 P16050 1/20 0.36
CYP1A2 P05177 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
MAPT P10636 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
KMT2A Q03164 2/20 0.36
GLA P06280 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL496639 0.80 EDNRA (0.45) ALDH1A1HSD17B10HPGDKDM4ECA12
SCHEMBL8443507 0.77 NQO1 (0.49) ALDH1A1HSD17B10HPGDKDM4ECA12
SCHEMBL1355391 0.74 ALDH1A1 (0.52) ALDH1A1HSD17B10HPGDKDM4ECA12
SCHEMBL1549077 0.72 ALDH1A1 (0.57) ALDH1A1HSD17B10HPGDKDM4ECLCN2
SCHEMBL578127 0.71 CLCN2 (0.56) ALDH1A1HSD17B10HPGDKDM4ECA12
SCHEMBL31393718 0.70 EDNRA (0.43) ALDH1A1HSD17B10HPGDKDM4ECA12
Ammonia Solution, Strong SCHEMBL29557133 0.70 CLCN2 (0.54) ALDH1A1HSD17B10HPGDKDM4ECA12
SCHEMBL70977 0.70 HSD17B10 (0.48) ALDH1A1HSD17B10HPGDKDM4ECA12
Hydrochloric Acid SCHEMBL28802432 0.69 ALDH1A1 (0.53) ALDH1A1HSD17B10HPGDKDM4ECLCN2
SCHEMBL11732540 0.69 KDM4E (0.45) ALDH1A1KDM4EEDNRACYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
US-5856529-A ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-05 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed