Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.32 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676366 | 0.89 | GRM2 (0.33) | GRM2KCNQ4KCNQ5AAK1 | |
| SCHEMBL6675700 | 0.87 | GRM2 (0.35) | GRM2 | |
| SCHEMBL6678485 | 0.87 | GRM2 (0.35) | GRM2 | |
| SCHEMBL6681810 | 0.86 | GRM2 (0.39) | GRM2KCNQ4KCNQ5 | |
| SCHEMBL6678438 | 0.86 | GRM2 (0.35) | GRM2 | |
| SCHEMBL7239503 | 0.85 | GRM2 (0.34) | GRM2 | |
| SCHEMBL6677564 | 0.84 | CA12 (0.35) | GRM2 | |
| SCHEMBL6679814 | 0.82 | GRM2 (0.33) | GRM2 | |
| SCHEMBL6676778 | 0.82 | RXRA (0.35) | GRM2 | |
| SCHEMBL6675190 | 0.81 | PLA2G7 (0.34) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |