Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.64 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.64 |
| ▸ | ITGAL | P20701 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4303059 | 0.92 | ITGB2 (0.53) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL29382085 | 0.91 | CYP2D6 (0.64) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL8368777 | 0.87 | KDM1A (0.54) | CYP2D6CYP2C19LMNACYP1A2HTR1A | |
| SCHEMBL17482006 | 0.83 | ITGB2 (0.47) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL30349623 | 0.82 | ITGB2 (0.70) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL28997940 | 0.82 | ITGB2 (0.70) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL7066913 | 0.82 | CYP2D6 (0.70) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL14707051 | 0.81 | ITGB2 (0.68) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL6637375 | 0.81 | LMNA (0.74) | ITGB2ICAM1ITGALCYP2D6CYP2C19 | |
| SCHEMBL14292499 | 0.81 | ITGB2 (0.72) | ITGB2ICAM1ITGALCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9862684-B2 | Modulation of K2P channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-01-09 | — | — | US | disclosed |
| US-9862684-B2 | Modulation of K2P channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| WO-2004037192-A2 | IDENTIFICATION OF ANTIMYCOBACTERIAL TARGETS AND THE INHIBITION THEREOF AS A TREATMENT FOR INFECTIOUS DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031814-A1 | MODULATION OF K2P CHANNELS | KCNJ2, KCNK2, KCNN3 | ITGB2 2330/4885ICAM1 1755/4885ITGAL 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.