Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674764 | 0.88 | POLB (0.45) | NR1H4PPARGMEN1TP53GAA | |
| SCHEMBL6673929 | 0.83 | NR1H4 (0.50) | NR1H4EPHX2PPARGSERPINE1PPARA | |
| SCHEMBL6674562 | 0.75 | NR1H4 (0.56) | NR1H4EPHX2PPARGSERPINE1PPARA | |
| SCHEMBL6674068 | 0.73 | POLB (0.46) | NR1H4EPHX2PPARGMEN1TP53 | |
| SCHEMBL6673833 | 0.66 | RARA (0.53) | NR1H4EPHX2MEN1KMT2A | |
| SCHEMBL6676941 | 0.65 | TRPA1 (0.47) | NR1H4EPHX2MEN1TP53GAA | |
| SCHEMBL5693694 | 0.65 | SERPINE1 (0.65) | NR1H4PPARGSERPINE1PPARAMEN1 | |
| SCHEMBL21297713 | 0.65 | HCAR2 (0.41) | NR1H4EPHX2MEN1KMT2A | |
| SCHEMBL2301205 | 0.65 | KDM4E (0.54) | NR1H4EPHX2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL6109346 | 0.65 | SERPINE1 (0.77) | NR1H4PPARGSERPINE1PPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862555-B1 | SUBSTITUTED ARYL OR HETEROARYLAMIDES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN INC (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6610744-B2 | Administering to a mammal a retinoid campound which binds specifically or selectively to a RAR alpha retinoid receptors in preference over RAR beta and RAR Gamma retinoid receptors, for therapy and prophylaxisof disease or condition | ALLERGAN, INC. | 2003-08-26 | — | — | US | disclosed |