Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 4/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5399629 | 0.90 | PDE1A (0.38) | PDE1APDE1BPDE1CSLC16A1PDE2A | |
| SCHEMBL5400486 | 0.87 | SLC16A1 (0.43) | SLC16A1TSHR | |
| SCHEMBL5419638 | 0.86 | PDE1A (0.39) | PDE1APDE1BPDE1CSLC16A1PDE2A | |
| SCHEMBL5395371 | 0.83 | SLC16A1 (0.52) | PDE1APDE1BPDE1CSLC16A1PDE5A | |
| SCHEMBL5404652 | 0.83 | RIPK3 (0.41) | PDE1APDE1BPDE1CPDE5ARIPK3 | |
| SCHEMBL5405541 | 0.82 | PDE5A (0.39) | PDE1APDE1BPDE1CSLC16A1PDE2A | |
| SCHEMBL5419589 | 0.81 | PDE1A (0.52) | PDE1APDE1BPDE1CPDE2AADORA1 | |
| SCHEMBL5395309 | 0.80 | PDE1A (0.37) | PDE1APDE1BPDE1CSLC16A1PDE2A | |
| SCHEMBL5403011 | 0.80 | ADORA2A (0.40) | PDE1APDE1BPDE1CSLC16A1PDE5A | |
| SCHEMBL5402794 | 0.80 | PDE1B (0.41) | PDE1APDE1BPDE1CPDE2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |