Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 6/20 | 0.41 |
| ▸ | PDE1A | P54750 | 5/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.41 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419589 | 0.87 | PDE1A (0.52) | PDE1BPDE1APDE1CADORA1ADORA3 | |
| SCHEMBL5402553 | 0.84 | PDE1A (0.41) | PDE1BPDE1APDE1CADORA1TSHR | |
| SCHEMBL5403451 | 0.84 | PDE1A (0.44) | PDE1BPDE1APDE1CALDH1A1PDE2A | |
| SCHEMBL5393375 | 0.84 | KMT2A (0.46) | PDE1BPDE1APDE1CADORA1TSHR | |
| SCHEMBL5400574 | 0.84 | ADORA2B (0.48) | PDE1BPDE1APDE1CADORA1TSHR | |
| SCHEMBL5399629 | 0.82 | PDE1A (0.38) | PDE1BPDE1APDE1CRIPK3ADORA1 | |
| SCHEMBL5404652 | 0.82 | RIPK3 (0.41) | PDE1BPDE1APDE1CRIPK3PDE5A | |
| SCHEMBL5407727 | 0.82 | PDE1A (0.45) | PDE1BPDE1APDE1CTSHRALDH1A1 | |
| SCHEMBL5393363 | 0.82 | PDE1A (0.40) | PDE1BPDE1APDE1CALDH1A1PDE2A | |
| SCHEMBL5415082 | 0.82 | SLC16A1 (0.36) | PDE1BPDE1APDE1CRIPK3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | PDE1B 4206/4885PDE1A 4056/4885PDE1C 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.