SCHEMBL667762

SCHEMBL667762

O=C(O)C(=C/C1=C/CCCCCCCCCC1)C(/C1=C/CCCCCCCCCC1)(/C1=C/CCCCCCCCCC1)/C1=C/CCCCCCCCCC1

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15135111 0.79
SCHEMBL634692 0.75 HDAC4 (0.38) HDAC4HDAC2HDAC8HDAC6
SCHEMBL153820 0.75 HDAC4 (0.38) HDAC4HDAC2HDAC8HDAC6
SCHEMBL11138198 0.75 HDAC4 (0.38) HDAC4HDAC2HDAC8HDAC6
SCHEMBL156064 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6
SCHEMBL7994473 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6
SCHEMBL155074 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6
SCHEMBL7994476 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6
SCHEMBL155075 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6
SCHEMBL8080804 0.72 AKR1C3 (0.40) HDAC4HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9329474-B2 Photoresist composition and resist pattern-forming method JSR CORPORATION (JP) 2016-05-03 US disclosed
US-9200098-B2 Radiation-sensitive composition and compound JSR CORPORATION (JP) 2015-12-01 US disclosed
US-9120726-B2 Radiation-sensitive resin composition, compound and producing method of compound JSR CORPORATION (JP) 2015-09-01 US disclosed
US-8968980-B2 Radiation-sensitive resin composition and compound JSR CORPORATION (JP) 2015-03-03 US disclosed
US-20130280657-A1 PHOTORESIST COMPOSITION AND RESIST PATTERN-FORMING METHOD JSR CORPORATION (JP) 2013-10-24 US disclosed
US-8470513-B2 Radiation-sensitive resin composition and polymer JSR CORPORATION (JP) 2013-06-25 US disclosed
US-8389202-B2 Polymer, radiation-sensitive composition, monomer, and method of producing compound JSR CORPORATION (JP) 2013-03-05 US disclosed
US-20120258399-A1 RADIATION-SENSITIVE RESIN COMPOSITION, COMPOUND AND PRODUCING METHOD OF COMPOUND JSR CORPORATION (JP) 2012-10-11 US disclosed
US-20120178024-A1 POLYMER, RADIATION-SENSITIVE COMPOSITION, MONOMER, AND METHOD OF PRODUCING COMPOUND JSR CORPORATION (JP) 2012-07-12 US disclosed
US-20120045719-A1 RADIATION-SENSITIVE RESIN COMPOSITION AND COMPOUND JSR CORPORATION (JP) 2012-02-23 US disclosed
US-7977442-B2 Radiation-sensitive composition, polymer and monomer JSR CORPORATION (JP) 2011-07-12 US disclosed
US-20100331440-A1 RADIATION-SENSITIVE COMPOSITION, POLYMER AND MONOMER JSR CORPORATION (JP) 2010-12-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120045719-A1 RADIATION-SENSITIVE RESIN COMPOSITION AND COMPOUND RFT1, RER1, ZYX HDAC4 1287/4885HDAC2 997/4885HDAC8 1835/4885
US-20100331440-A1 RADIATION-SENSITIVE COMPOSITION, POLYMER AND MONOMER ALG1, MRE11, PCNA HDAC4 2938/4885HDAC2 1934/4885HDAC8 3404/4885
US-20120178024-A1 POLYMER, RADIATION-SENSITIVE COMPOSITION, MONOMER, AND METHOD OF PRODUCING COMPOUND RAD51, PYM1, MRE11 HDAC4 2597/4885HDAC2 909/4885HDAC8 2858/4885
US-20120258399-A1 RADIATION-SENSITIVE RESIN COMPOSITION, COMPOUND AND PRODUCING METHOD OF COMPOUND RAD51, RER1, RXRA HDAC4 1811/4885HDAC2 1247/4885HDAC8 1818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.