Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | KMO | O15229 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320065 | 0.84 | KMO (0.47) | TSHRSRD5A2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL28626237 | 0.79 | TSHR (0.50) | TSHRSRD5A2KDM4EMAPTHPGD | |
| SCHEMBL21448794 | 0.76 | TSHR (0.52) | TSHRSRD5A2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL21448791 | 0.76 | TSHR (0.52) | TSHRSRD5A2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL15319178 | 0.76 | TSHR (0.52) | TSHRSRD5A2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8352471 | 0.72 | TSHR (1.00) | TSHRSRD5A2KMOPKMKDM4E | |
| SCHEMBL371998 | 0.72 | TSHR (1.00) | TSHRSRD5A2KMOPKMKDM4E | |
| SCHEMBL29353637 | 0.72 | TSHR (1.00) | TSHRSRD5A2KMOPKMKDM4E | |
| SCHEMBL4385239 | 0.72 | CES2 (0.46) | TSHRKDM4EMEN1NPC1MAPT | |
| SCHEMBL14563971 | 0.70 | MAPT (0.60) | TSHRSRD5A2CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1475385-A1 | Glycoside derivatives of 2-(3,4-dichlorobenzoyl)-cycopropane-1-carboxylic acid | Newron Pharmaceuticals S.p.A. (IT) | 2004-11-10 | — | — | EP | disclosed |