SCHEMBL6678078

SCHEMBL6678078

CC/N=C(/NC(=O)OC(C)(C)C)Nc1ccc(Cl)c(CN(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 4/20 0.36
KMT2A Q03164 3/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 1/20 0.36
NR1H4 Q96RI1 1/20 0.35
MCHR1 Q99705 1/20 0.35
POLB P06746 1/20 0.34
MEN1 O00255 2/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
IDO1 P14902 1/20 0.32
CYP17A1 P05093 1/20 0.32
STAT3 P40763 1/20 0.32
KCNJ5 P48544 2/20 0.32
KCNJ3 P48549 2/20 0.32
PTPN11 Q06124 1/20 0.32
KCNJ6 P48051 1/20 0.32
GAA P10253 1/20 0.32
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6679938 0.92 NR1H4 (0.36) MAPKAPK2ALDH1A1NR1H4MCHR1CYP17A1
SCHEMBL6675974 0.91 CA1 (0.36) MAPKAPK2KMT2AALDH1A1HPGDNR1H4
SCHEMBL6675630 0.90 NR1H4 (0.35) MAPKAPK2ALDH1A1HPGDNR1H4MCHR1
SCHEMBL6679119 0.89 NR1H4 (0.35) MAPKAPK2ALDH1A1NR1H4MCHR1CYP17A1
SCHEMBL6675977 0.89 NR1H4 (0.35) MAPKAPK2KMT2AALDH1A1HPGDNR1H4
SCHEMBL6681133 0.88 NR1H4 (0.34) MAPKAPK2ALDH1A1NR1H4MCHR1CYP17A1
SCHEMBL6684393 0.87 NR1H4 (0.34) MAPKAPK2ALDH1A1NR1H4MCHR1CYP17A1
SCHEMBL6686106 0.86 NR1H4 (0.33) MAPKAPK2ALDH1A1NR1H4MCHR1CYP17A1
SCHEMBL6682277 0.85 KDM4E (0.39) KMT2AALDH1A1HPGDNR1H4MEN1
SCHEMBL6682103 0.83 AKT1 (0.37) MAPKAPK2ALDH1A1NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0798292-B1 ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) 2004-11-03 EP disclosed
US-6534546-B1 Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-03-18 US disclosed
EP-0798292-A1 ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY Chugai Seiyaku Kabushiki Kaisha (JP) 1997-10-01 EP disclosed