Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678101 | 0.84 | MAPK14 (1.00) | MAPK14PDE4DCYP1A2CYP3A4EGFR | |
| SCHEMBL6677756 | 0.84 | MAPK14 (1.00) | MAPK14CYP1A2CYP3A4CYP2C19EGFR | |
| SCHEMBL6681443 | 0.79 | MAPT (0.57) | MAPK14CYP1A2CYP3A4MAPTALDH1A1 | |
| SCHEMBL6782336 | 0.77 | MAPK14 (1.00) | MAPK14CYP1A2CYP3A4MAPTALDH1A1 | |
| SCHEMBL6781511 | 0.77 | MAPK14 (1.00) | MAPK14CYP1A2CYP3A4MAPTALDH1A1 | |
| SCHEMBL6679437 | 0.76 | MAPK14 (1.00) | MAPK14CYP1A2CYP3A4EGFRMAPT | |
| SCHEMBL7755234 | 0.75 | MAPK14 (0.92) | MAPK14CYP1A2CYP3A4EGFRMAPT | |
| SCHEMBL27527556 | 0.74 | MAPK14 (0.75) | MAPK14CYP1A2CYP3A4EGFRMAPT | |
| SCHEMBL2980389 | 0.74 | MAPK14 (0.86) | MAPK14CYP1A2CYP3A4MAPTALDH1A1 | |
| SCHEMBL6678591 | 0.73 | MAPT (0.50) | MAPK14MAPTALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188389-C | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRA ZENECA LTD (SE) | 2005-02-09 | — | — | CN | disclosed |
| EP-1077930-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| US-6465455-B1 | TUMOUR NECROSIS FACTOR AND INTERLEUKIN FAMILY INHIBITORS; INHIBITION OF ENZYME P38 KINASE; INFLAMMATION, IMMUNO-REGULATION, ALLERGIES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-1077930-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059960-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |