Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674831 | 0.91 | PTPN1 (0.39) | ALDH1A1GAAKMT2AMAPTPTPN1 | |
| SCHEMBL6676957 | 0.88 | EGFR (0.43) | MAPTNAMPT | |
| SCHEMBL6681088 | 0.87 | ALDH1A1 (0.44) | ALDH1A1GAALMNAHTTKMT2A | |
| SCHEMBL6680475 | 0.86 | CYP2C9 (0.42) | LMNAKMT2AKDM4EMEN1MAPT | |
| SCHEMBL6689914 | 0.84 | ALDH1A1 (0.41) | ALDH1A1GAAHTTKMT2AMEN1 | |
| SCHEMBL6681938 | 0.84 | HTT (0.39) | ALDH1A1GAALMNAHTTKMT2A | |
| SCHEMBL6678684 | 0.82 | ALDH1A1 (0.43) | ALDH1A1GAALMNAHTTKMT2A | |
| SCHEMBL6675896 | 0.82 | ALDH1A1 (0.41) | ALDH1A1GAALMNAHTTKMT2A | |
| SCHEMBL6680600 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAALMNAKMT2AKDM4E | |
| SCHEMBL7247258 | 0.78 | ALDH1A1 (0.56) | ALDH1A1GAALMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |