Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674831 | 0.89 | PTPN1 (0.39) | ESRRAMAPTTDP1PPARDKMT2A | |
| SCHEMBL6678686 | 0.86 | ALDH1A1 (0.43) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL6681039 | 0.86 | C5AR1 (0.39) | CYP2C9PTGER1C5AR1SYKKDM4E | |
| SCHEMBL6680473 | 0.85 | CYP2C9 (0.42) | CYP2C9PTGER1ESRRACCR5LMNA | |
| SCHEMBL6676957 | 0.82 | EGFR (0.43) | MAPTTDP1HDAC1NAMPT | |
| SCHEMBL6675952 | 0.81 | CYP2C9 (0.45) | CYP2C9PTGER1ESRRACCR5LMNA | |
| SCHEMBL27564883 | 0.80 | CYP2C9 (0.45) | CYP2C9PTGER1ESRRACCR5LMNA | |
| SCHEMBL6681429 | 0.78 | C5AR1 (0.47) | CYP2C9PTGER1MAPTC5AR1P2RX4 | |
| SCHEMBL6680479 | 0.77 | CYP2C9 (0.39) | CYP2C9PTGER1CCR5LMNAPPARG | |
| SCHEMBL6681426 | 0.77 | CYP2C9 (0.42) | CYP2C9PTGER1ESRRACCR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |