SCHEMBL667916

SCHEMBL667916

NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(Oc3ccccc3)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA2 P00918 16/20 1.00
CA1 P00915 15/20 1.00
CA9 Q16790 15/20 1.00
CA12 O43570 14/20 1.00
KMT2A Q03164 2/20 0.70
SOS1 Q07889 1/20 0.70
CA4 P22748 2/20 0.70
CA7 P43166 2/20 0.70
PTPN7 P35236 1/20 0.60
MEN1 O00255 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL671546 0.87 CA2 (1.00) CA2CA1CA9CA12KMT2A
SCHEMBL30053559 0.85 CA12 (0.73) CA2CA1CA9CA12KMT2A
SCHEMBL11831971 0.85 KMT2A (0.82) CA2CA1CA9CA12KMT2A
SCHEMBL28899751 0.85 CA2 (0.74) CA2CA1CA9CA12KMT2A
SCHEMBL21295380 0.84 CA12 (0.71) CA2CA1CA9CA12KMT2A
SCHEMBL6515525 0.83 SOS1 (1.00) CA2CA1CA9CA12SOS1
SCHEMBL28499329 0.83 KMT2A (1.00) CA2CA1CA9CA12KMT2A
SCHEMBL22446513 0.82 CA2 (0.70) CA2CA1CA9CA12KMT2A
SCHEMBL23086242 0.81 CA2 (0.87) CA2CA1CA9CA12KMT2A
SCHEMBL241662 0.80 CA2 (0.67) CA2CA1CA9CA12KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US claimed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP claimed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO claimed
US-20190015379-A1 USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF, TOGETHER WITH RADIATION, TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME AND SUPPRESS PROLIFERATION OF CANCER STEM CELLS DEL MAR PHARMACEUTICALS (BC) LTD. (CA) 2019-01-17 US disclosed
US-9962398-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2018-05-08 US disclosed
US-9962398-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2018-05-08 US disclosed
EP-3217970-A1 DIANHYDROGALACTITOL TOGETHER WITH RADIATION TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME Del Mar Pharmaceuticals (CA) 2017-09-20 EP disclosed
EP-2590938-B1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC (CA) 2017-06-07 EP disclosed
US-20170007627-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC. (CA) 2017-01-12 US disclosed
US-20170007627-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH WELICHEM BIOTECH INC. (CA) 2017-01-12 US disclosed
US-9463171-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2016-10-11 US disclosed
US-9463171-B2 Sulfonamide compounds for inhibition of metastatic tumor growth WELICHEM BIOTECH INC. (CA) 2016-10-11 US disclosed
WO-2016077264-A1 DIANHYDROGALACTITOL TOGETHER WITH RADIATION TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME DEL MAR PHARMACEUTICALS (CA) 2016-05-19 WO disclosed
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US disclosed
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2013-07-25 US disclosed
EP-2590938-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH Metasignal Therapeutics Inc. (CA) 2013-05-15 EP disclosed
WO-2012021963-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH METASIGNAL THERAPEUTICS INC. (CA) 2012-02-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190396-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH HIF1AN, CBX2, HIF1A CA2 5/4885CA1 31/4885CA9 25/4885
US-20190015379-A1 USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF, TOGETHER WITH RADIATION, TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND GLIOBLASTOMA MULTIFORME AND SUPPRESS PROLIFERATION OF CANCER STEM CELLS MGMT, DCLRE1A, DNMT1 CA2 4654/4885CA1 2097/4885CA9 3444/4885
US-20170007627-A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH HIF1AN, CBX2, HIF1A CA2 5/4885CA1 31/4885CA9 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.