Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675209 | 0.83 | FAAH (0.40) | NQO2MTNR1AMTNR1BCA12CA1 | |
| SCHEMBL6675910 | 0.81 | MTNR1A (0.48) | NQO2MTNR1AMTNR1BCA12CA1 | |
| SCHEMBL6675303 | 0.80 | NQO2 (0.40) | NQO2MTNR1AMTNR1BMAPTKDM4E | |
| SCHEMBL6675049 | 0.80 | KMT2A (0.55) | CA12CA1CA2CA9MAPT | |
| SCHEMBL29814877 | 0.80 | MTNR1A (0.59) | NQO2MTNR1AMTNR1BMAPTRAB9A | |
| SCHEMBL6675304 | 0.79 | MTNR1A (0.41) | NQO2MTNR1AMTNR1BMAPTKDM4E | |
| SCHEMBL7239004 | 0.79 | NQO2 (0.41) | NQO2MTNR1AMTNR1BCA12CA1 | |
| SCHEMBL3152901 | 0.79 | MTNR1A (0.48) | NQO2MTNR1AMTNR1BCA12CA1 | |
| SCHEMBL5981610 | 0.79 | MTNR1A (0.48) | NQO2MTNR1AMTNR1B | |
| SCHEMBL6676121 | 0.78 | CA1 (0.46) | NQO2CA1CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |