Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gliclazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gliclazide SCHEMBL1537023 | 0.90 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL291434 | 0.90 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL16387 | 0.90 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL239075 | 0.89 | ALDH1A1 (0.97) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL30011556 | 0.85 | ALDH1A1 (0.86) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL6344915 | 0.84 | ALDH1A1 (0.88) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL1967443 | 0.81 | ALDH1A1 (0.77) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| SCHEMBL17309638 | 0.80 | ALDH1A1 (0.76) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| SCHEMBL17309632 | 0.79 | ALDH1A1 (0.74) | ALDH1A1LMNAAKR1C3GAAKDM4E | |
| Gliclazide SCHEMBL22069924 | 0.79 | ALDH1A1 (0.72) | ALDH1A1LMNAAKR1C3GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1622799-A | Pharmaceutical composition for sustained or continuous releasing therapeutic active components | INDIAN INST TECHNOLOGY (IN) | 2005-06-01 | — | — | CN | disclosed |
| EP-1469824-A1 | PHARMACEUTICAL COMPOSITION FOR EXTENDED/SUSTAINED RELEASE OF THERAPEUTICALLY ACTIVE INGREDIENT | Council of Scientific and Industrial Research (IN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003063825-A1 | PHARMACEUTICAL COMPOSITION FOR EXTENDED/SUSTAINED RELEASE OF THERAPEUTICALLY ACTIVE INGREDIENT | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-08-07 | — | — | WO | disclosed |