Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gliclazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.88 |
| ▸ | LMNA | P02545 | 2/20 | 0.88 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.88 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 1/20 | 0.79 |
| ▸ | GLA | P06280 | 1/20 | 0.79 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gliclazide SCHEMBL16387 | 0.94 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL291434 | 0.94 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL1537023 | 0.94 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL239075 | 0.93 | ALDH1A1 (0.97) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Tolazamide SCHEMBL13725632 | 0.89 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Tolazamide SCHEMBL34417 | 0.89 | ALDH1A1 (1.00) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Tolazamide SCHEMBL28562527 | 0.87 | ALDH1A1 (0.97) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL30011556 | 0.87 | ALDH1A1 (0.86) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL6679802 | 0.84 | ALDH1A1 (0.80) | ALDH1A1LMNAAKR1C3GAAMAPT | |
| Gliclazide SCHEMBL1967443 | 0.82 | ALDH1A1 (0.77) | ALDH1A1LMNAAKR1C3GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050048144-A1 | Herb extract-based cosmeceutical cream for controlling the blood sugar level of diabetes and methods for making it | HAN XIAO-QING (US) | 2005-03-03 | — | — | US | disclosed |