Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053347 | 0.94 | ADAM17 (0.53) | ADAM17MMP13MMP12MMP2ADAMTS4 | |
| SCHEMBL4048582 | 0.89 | ADAM17 (0.46) | ADAM17MMP13MMP12MMP3MMP7 | |
| SCHEMBL6680135 | 0.87 | KDM4E (0.43) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL4050868 | 0.86 | ADAM17 (0.53) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL4056012 | 0.86 | ADAM17 (0.53) | ADAM17MMP13MMP12MMP2ADAMTS4 | |
| SCHEMBL4049644 | 0.84 | MMP13 (0.54) | ADAM17MMP13MMP12MMP2ADAMTS4 | |
| SCHEMBL4052521 | 0.83 | ADAM17 (0.54) | ADAM17MMP13MMP12MMP2ADAMTS4 | |
| SCHEMBL4056043 | 0.81 | ADAM17 (0.59) | ADAM17MMP13MMP12MMP2MMP3 | |
| SCHEMBL6688203 | 0.81 | MMP13 (0.51) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL4052925 | 0.79 | ADAM17 (0.57) | ADAM17MMP13MMP12MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397137-A4 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1397137-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002096426-A1 | HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |