Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 5/20 | 0.56 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | AIMP2 | Q13155 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712159 | 0.92 | SMG1 (0.57) | CAMK2DSMG1CDK1CDK2AIMP2 | |
| SCHEMBL6109026 | 0.77 | CSNK2A1 (0.69) | CAMK2DSMG1CDK1CDK2ABL1 | |
| SCHEMBL7811447 | 0.74 | CSNK2A1 (0.72) | CAMK2DSMG1CDK1CDK2ABL1 | |
| SCHEMBL3608464 | 0.73 | GSK3B (0.53) | CAMK2DSMG1CDK1CDK2ABL1 | |
| SCHEMBL8254301 | 0.73 | PIK3CG (0.69) | CAMK2DCDK2ABL1BCRMAPT | |
| SCHEMBL6107663 | 0.73 | SMG1 (1.00) | CAMK2DSMG1CDK1CDK2ABL1 | |
| SCHEMBL3251327 | 0.73 | AIMP2 (0.48) | CAMK2DSMG1CDK1CDK2AIMP2 | |
| SCHEMBL3607489 | 0.72 | CAMK2D (0.55) | CAMK2DSMG1CDK1CDK2ABL1 | |
| SCHEMBL14423386 | 0.72 | CAMK2D (0.56) | CAMK2DSMG1CDK1CDK2AIMP2 | |
| SCHEMBL13698056 | 0.71 | KDR (0.59) | CAMK2DSMG1CDK1CDK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373257-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079197-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-10 | — | — | WO | disclosed |