SCHEMBL6680810

SCHEMBL6680810

NC[C@@H]1C[C@H]1c1cccc2c1OCCO2

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 19/20 0.51
HTR2B P41595 18/20 0.51
HTR2A P28223 12/20 0.51
SLC6A2 P23975 2/20 0.49
SLC6A4 P31645 2/20 0.49
SLC6A3 Q01959 1/20 0.49
DRD2 P14416 1/20 0.43
MAOB P27338 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6680808 1.00 HTR2C (0.51) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL6679348 0.87 HTR2C (0.51) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL6679351 0.87 HTR2C (0.51) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL6679689 0.84 DRD2 (0.46) DRD2MAOB
SCHEMBL6679688 0.84 DRD2 (0.46) DRD2MAOB
SCHEMBL6682129 0.79 MTNR1B (0.59) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL17269309 0.79 MTNR1B (0.59) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL6681416 0.79 MTNR1B (0.59) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL6677544 0.79 HTR2C (0.50) HTR2CHTR2BHTR2ASLC6A2SLC6A4
SCHEMBL15255143 0.79 MTNR1B (0.59) HTR2CHTR2BHTR2ASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027043-B1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2004-11-10 EP disclosed
EP-1027043-A4 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL MYERS SQUIBB CO (US) 2002-02-20 EP disclosed
EP-1027043-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS Bristol-Myers Squibb Company (US) 2000-08-16 EP disclosed
US-6060506-A FOR TREATMENT OF SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-09 US disclosed
US-5981571-A USEFUL AS MELATONERGIC AGENTS IN THE TREATMENT OF SLEEP DISORDERS, SEASONAL DEPRESSION, SHIFTS IN CIRCADIAN CYCLES, MELANCHOLIA, STRESS, APPETITE REGULATION, BENIGN PROSTATIC HYPERPLASIA AND RELATED CONDITIONS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-11-09 US disclosed
US-5856529-A ADJUSTMENT OF NERVOUS SYSTEM, ENDOCRINE FUNCTION; REPRODUCTION, BODY WEIGHT AND METABOLISM BRISTOL-MYERS SQUIBB COMPANY (US) 1999-01-05 US disclosed
WO-1998025606-A1 BENZODIOXOLE, BENZOFURAN, DIHYDROBENZOFURAN, AND BENZODIOXANE MELATONERGIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-18 WO disclosed