Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6684639 | 0.89 | LMNA (0.57) | FGFR1PDPK1LMNAALDH1A1HPGD | |
| SCHEMBL6689654 | 0.89 | FGFR1 (0.57) | FGFR1PDPK1LMNAALDH1A1HPGD | |
| SCHEMBL6684888 | 0.85 | EGFR (0.52) | LMNAHPGDHTTEGFRTTBK1 | |
| SCHEMBL8115114 | 0.81 | EGFR (0.70) | EGFRPDGFRBCDK1ABL1PDGFRA | |
| SCHEMBL31236246 | 0.79 | PDPK1 (0.56) | FGFR1PDPK1LMNAALDH1A1HPGD | |
| SCHEMBL31236247 | 0.79 | PDPK1 (0.56) | FGFR1PDPK1LMNAALDH1A1HPGD | |
| SCHEMBL19507722 | 0.78 | EGFR (0.49) | FGFR1LMNAALDH1A1HPGDHTT | |
| SCHEMBL13861667 | 0.78 | TTBK1 (0.52) | LMNAEGFRKDRTTBK1TTBK2 | |
| SCHEMBL9607661 | 0.78 | F9 (0.67) | FGFR1LMNAALDH1A1HPGDHTT | |
| SCHEMBL149528 | 0.77 | KDR (0.52) | ALDH1A1HPGDEGFRKDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |