Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | PRKCA | P17252 | 3/20 | 0.52 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235344 | 0.90 | EGFR (0.55) | EGFRABL1PRKCAABL2SRC | |
| SCHEMBL19507722 | 0.88 | EGFR (0.49) | EGFRABL1PRKCAABL2SRC | |
| SCHEMBL6686751 | 0.87 | EGFR (0.52) | EGFRABL1PRKCAABL2SRC | |
| SCHEMBL6684639 | 0.86 | LMNA (0.57) | EGFRABL1PRKCAABL2SRC | |
| SCHEMBL6681340 | 0.85 | FGFR1 (0.57) | EGFRABL1PRKCAMAPK1MAPT | |
| SCHEMBL13861667 | 0.85 | TTBK1 (0.52) | EGFRABL1PRKCAABL2SRC | |
| SCHEMBL19507769 | 0.82 | EGFR (0.52) | EGFRABL1PRKCASRCCDK1 | |
| SCHEMBL6682618 | 0.82 | EGFR (0.49) | EGFRABL1PRKCASRCCDK1 | |
| SCHEMBL6689654 | 0.81 | FGFR1 (0.57) | EGFRABL1PRKCAMAPK1MAPT | |
| SCHEMBL6238000 | 0.79 | ABCG2 (0.51) | EGFRABL1PRKCAABL2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832092-B1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0832092-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040706-A1 | ORALLY ACTIVE ADENOSINE KINASE INHIBITORS | GENSIA-SICOR (US) | 1996-12-19 | — | — | WO | disclosed |