Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 11/20 | 0.49 |
| ▸ | DRD1 | P21728 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15690262 | 0.87 | KDM4E (0.73) | KDM4ETSHRALOX15SIRT1DRD3 | |
| SCHEMBL3785757 | 0.85 | KDM4E (0.75) | KDM4ETSHRALOX15SIRT1DRD3 | |
| SCHEMBL15690244 | 0.82 | AOC3 (0.56) | KDM4ETSHRALOX15SIRT1DRD3 | |
| SCHEMBL15691861 | 0.82 | BCAT2 (0.47) | KDM4ETSHRALOX15SIRT1BCAT2 | |
| SCHEMBL7149691 | 0.82 | ITGB3 (0.51) | MEN1KMT2A | |
| SCHEMBL7686132 | 0.81 | DRD3 (0.53) | KDM4ETSHRALOX15SIRT1DRD3 | |
| SCHEMBL30183479 | 0.81 | DRD3 (0.53) | KDM4ETSHRALOX15SIRT1DRD3 | |
| SCHEMBL24169509 | 0.80 | MAPT (0.74) | KDM4ETSHRALOX15MEN1POLB | |
| SCHEMBL11395534 | 0.80 | CHRM2 (0.60) | KDM4ETSHRALOX15SIRT1ACHE | |
| SCHEMBL30183548 | 0.79 | DRD3 (0.57) | DRD3DRD1DRD2ACHEDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004004727-A1 | 3,4-DIHYDROISOQUINOLIN-1-ONE DERIVATIVES AS INDUCERS OF APOPTOSIS | AXYS PHARMACEUTICALS, INC. (US) | 2004-01-15 | — | — | WO | disclosed |